CBDV, or cannabidivarin, is starting to get some media attention lately. And, while hemp research has been hindered for decades by international prohibition, thankfully there are intrepid scientists who wade through rivers of restrictive governmental red tape in order to conduct groundbreaking cannabinoid research.
Here we’ll explore what CBDV is and some of the ongoing research into CBDV’s potential therapeutic applications. We’ll also discuss how to get hemp flower high in CBDV and how to extract it from the plant.
What Is CBDV?
Here’s where we get a little technical. Cannabidivarin (CBDV) is one of over one hundred phytocannabinoids found in cannabis. Although it is not typically found in high concentrations, some cultivars, such as Forbidden V and Pine Walker, have been bred to express substantial quantities of CBDV.
CBDV is the decarboxylated, or activated form of, cannabidivarinic acid (CBDVA). This non-intoxicating molecule was first isolated in 1969 and has been shown to have a weak affinity for both CB1 and CB2 receptors1. CBDV is the chemical precursor to THCV.
CBDV Vs. CBD: What’s The Difference?
The differences between CBDV vs. CBD start at the molecular level. Whereas CBD has a pentyl (5) chain of carbons, CBDV only has a propyl (3) chain. CBDV is just like CBD in every other way— it just has a shorter carbon tail!
That’s not where the differences end though. CBDV has also been observed interacting with transient receptor potential TRP channels. TRP channels are involved in2:
- Production of inflammatory mediators
- Cell migration
What Are Researchers Finding— Potential CBDV Benefits
Researchers have taken note of CBDV as a potentially useful cannabinoid for various therapeutic applications owing to the fact that it doesn’t produce intoxicating effects.
Here is a list of research regarding CBDV:
- GW Pharmaceuticals is planning a phase 2 clinical trial of a CBDV-containing drug to treat epilepsy in adults1,10.
- Drugs containing CBDV are being researched for the treatment of children and adults with Autism Spectrum Disorder3,4.
- “Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome5”
- Research with rats indicates CBDV may be useful for reducing nausea6.
- Study of non-intoxicating phytocannabinoids, including CBDV, using mice modeling Duchenne muscular dystrophy (DMD)7.
- A phase 2 clinical trial is underway to explore whether cannabis oil containing CBDV (and other cannabinoids) could be helpful for adults with ADHD8.
- A 2016 study suggested that CBDV might provide relief from acne1,9.
Where Can You Buy CBDV?
Good news! Sunset Lake CBD grows some cultivars that contain CBDV including Forbidden V. Forbidden V was bred by Oregon CBD and grown under the sun on our farm in South Hero, Vermont. With 6.85% CBDV and 11.94% CBD, the buds hold a lot of promise for a variety of uses.
Currently, Forbidden V is only available to wholesale customers. If you own a retail location or eCommerce site and are interested in carrying Forbidden V, please get in touch with us here.